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John Edmond, Ph.D.

Email Address:
jedmond@mednet.ucla.edu Mailing Address:
Mail Code: 173717
Los Angeles, CA 90095
UNITED STATES

Work Address:
Office
BSRB 310

UNITED STATES


Office Phone Number:
(310) 206-0367
Work Phone Number:
(310) 825-6535

Web Address:
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John Edmond, Ph.D.

Department / Division Affiliations
Advisor, Cellular and Molecular Biology of the Inner Ear Laboratory
Professor Emeritus, Biological Chemistry

Research Interest:

Developmental Neurochemistry and Metabolism

Developmental Neurochemistry and Metabolism My research interests encompass developmental neurobiochemistry and metabolism. The interest, by necessity, range from basic infant nutrition, the nutrient requirements for brain development to the metabolic diversity and specialization of neural cells from developing brain by their examination in primary cell culture. In considering the very basic issues, at what is recognized as the most vulnerable period in development, it would seem that energy maintenance at the massive brain growth spurt/onset of white matter formation would be a critical concern. At this time in development there is a high demand for lipids for the synthesis of new membrane in cell division for dynamic growth and for white matter formation, thus the origin and management of lipids in developing brain has been a focus of attention. The availability of dietary substances, such as the reduced availability of carbohydrate and as a consequence hypoglycemia, or the reduces availability of dietary iron and as a consequence, reduced oxygen delivery through anemia and depleted iron reserves, are conditions known to prevail during development. We have examined how these conditions influence the developing rat pup in a period when lipid accretion in the central nervous system is dynamic. The pursuit of our objectives has been facilitated by highly discriminating techniques such as the use of stable isotopes and mass isotopomer analysis by mass spectrometry, and by two model systems. The in-vivo model system involves the gastrostomy-reared rat pup (the artificially-reared rat pup) which can be fed milk substitutes containing specific nutrients to test our proposals. The second system available, the in-vitro model of pure populations of the major cell types from developing brain, astrocytes, oligodendrocytes and neurons. As with the gastrostomy-reared rat pup, the nutrient conditions of each neural cell population in primary culture can be manipulated in a precise way and the outcome examined. We are making use of substances containing stable isotopes such as carbon-13 and deuterium for our studies in vivo, and in-vitro, and the techniques of mass isotopomer analysis using gas chromatography coupled to a mass spectrometer to promote the studies and to obtain a definitive outcome. The primary focus at this time is to determine which fatty acids can access the brain and which cannot in an attempt to define the molecular characteristics of the monocarboxylic acid transporter(s) responsible for fatty acid delivery into brain.



Publications:

Lopez Ivan A, Acuna Dora, Shahram Yalda, Mowlds Donald, Ngan Amy M, Rungvivatjarus Tiranun, Sharma Yeshika, Edmond John Neuroglobin expression in the cochlea of rat pups exposed to chronic very mild carbon monoxide (25ppm) in air during and after the prenatal period. Brain research. 2010; 1327: 56-68.
Beltran-Parrazal Luis, Acuna Dora, Ngan Amy M, Kim Esther, Ngan Aileen, Kawakami Kyle, Edmond John, Lopez Ivan A Neuroglobin, cytoglobin, and transcriptional profiling of hypoxia-related genes in the rat cerebellum after prenatal chronic very mild carbon monoxide exposure (25ppm). Brain research. 2010; 1327: .
Lopez Ivan A, Acuna Dora, Beltran-Parrazal Luis, Lopez Ivan E, Amarnani Abhimanyu, Cortes Max, Edmond John Evidence for oxidative stress in the developing cerebellum of the rat after chronic mild carbon monoxide exposure (0.0025% in air). BMC neuroscience. 2009; 10: 53.
Lopez IA, Acuna D, Beltran-Parrazal L, Espinosa-Jeffrey A, Edmond J Oxidative stress and the deleterious consequences to the rat cochlea after prenatal chronic mild exposure to carbon monoxide in air. Neuroscience. 2008; 151(3): 854-67.
Galbraith Gary, Waschek James, Armstrong Brian, Edmond John, Lopez Ivan, Liu Weixin, Kurtz Ira Murine auditory brainstem evoked response: putative two-channel differentiation of peripheral and central neural pathways. Journal of neuroscience methods. 2006; 153(2): 214-20.
Webber Douglas S, Lopez Ivan, Korsak Rose A, Hirota Sean, Acuna Dora, Edmond John Limiting iron availability confers neuroprotection from chronic mild carbon monoxide exposure in the developing auditory system of the rat. Journal of neuroscience research. 2005; 80(5): 620-33.
Auestad Nancy, Stockard-Sullivan Janet, Innis Sheila M, Korsak Rose, Edmond John Auditory brainstem evoked response in juvenile rats fed rat milk formulas with high docosahexaenoic acid. Nutritional neuroscience. 2003; 6(6): 335-41.
Stockard-Sullivan Janet E, Korsak Rose A, Webber Douglas S, Edmond John Mild carbon monoxide exposure and auditory function in the developing rat. Journal of neuroscience research. 2003; 74(5): 644-54.
Lopez Ivan, Acuna Dora, Webber Douglas S, Korsak Rose A, Edmond John Mild carbon monoxide exposure diminishes selectively the integrity of the cochlea of the developing rat. Journal of neuroscience research. 2003; 74(5): 666-75.
Webber Douglas S, Korsak Rose A, Sininger Lauren K, Sampogna Sharon L, Edmond John Mild carbon monoxide exposure impairs the developing auditory system of the rat. Journal of neuroscience research. 2003; 74(5): 655-65.
Blake James W H, Webster Mark W I, Butler Rob, Edmond John J, Ruygrok Peter N Stent deployment with distal vascular protection for the culprit vein graft stenosis in a patient with an acute infarct and cardiogenic shock. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2002; 57(2): 234-8.
Espinosa-Jeffrey Araceli, Becker-Catania Sara G, Zhao Paul M, Cole Ruth, Edmond John, de Vellis Jean Selective specification of CNS stem cells into oligodendroglial or neuronal cell lineage: cell culture and transplant studies. Journal of neuroscience research. 2002; 69(6): 810-25.
Lee, WN Lim, S Bassilian, S Bergner, EA Edmond, J Fatty acid cycling in human hepatoma cells and the effects of troglitazone. The Journal of biological chemistry. . 1998; 273(33): 20929-34.
Edmond, J Higa, TA Korsak, RA Bergner, EA Lee, WN Fatty acid transport and utilization for the developing brain. Journal of neurochemistry. . 1998; 70(3): 1227-34.
Edmond, J Korsak, RA Morrow, JW Torok-Both, G Catlin, DH Dietary cholesterol and the origin of cholesterol in the brain of developing rats. The Journal of nutrition. . 1991; 121(9): 1323-30.
Auestad, N Korsak, RA Morrow, JW Edmond, J Fatty acid oxidation and ketogenesis by astrocytes in primary culture. Journal of neurochemistry. . 1991; 56(4): 1376-86.