Elizabeth F. Neufeld, Ph.D.
(Retired)

Email Address:
eneufeld@mednet.ucla.edu Laboratory Address:
Laboratory
BSRB 346
615 Charles E. Young Drive South
Los Angeles, CA 90095
UNITED STATES

Office Address:
Office
BSRB 350B
615 Charles E Young Drive South
Los Angeles, CA 90095
UNITED STATES


Work Phone Number:
310-825-7149
310-825-8722

Web Address:
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Elizabeth F. Neufeld, Ph.D.

Department / Division Affiliations
Emeritus Member, Brain Research Institute
Professor Emerita, Biological Chemistry

Research Interest:

The cause and treatment of the Sanfilippo syndrome
The Sanfilippo syndrome is a rare genetic disease of children, characterized by profound mental retardation and death in late adolescence. We study a mouse model of the disease to understand why the brain is so severely affected and to develop treatment.

Biography:

Born in France, Elizabeth Neufeld immigrated to the United States in 1940. She obtained a BS from Queens College, New York and a Ph.D. from the University of California Berkeley. After postdoctoral training in, she moved to the NIH in Bethesda, MD, where she began her studies of a rare group of genetic diseases. She moved back to California in 1984 as Chair of the Department of Biological Chemistry - a position that she occupied till 2004.

Publications:

Neufeld, Elizabeth F. From serendipity to therapy. Annual Reviews of Biochemistry 2011; 80: 1-15.
Ohmi Kazuhiro, Kudo Lili C, Ryazantsev Sergey, Zhao Hui-Zhi, Karsten Stanislav L, Neufeld Elizabeth F Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(20): 8332-7.
Chen Chi-hong B, Dellamaggiore Kenneth R, Ouellette Christopher P, Sedano Cecilia D, Lizadjohry Meikana, Chernis George A, Gonzales Michelle, Baltasar Francis E, Fan Audrey L, Myerowitz Rachel, Neufeld Elizabeth F Aptamer-based endocytosis of a lysosomal enzyme. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105(41): 15908-13.
Jordan M.C., Zheng Y., Ryazantsev S., Rozengurt N., Roos K.P., Neufeld E.F. Cardiac manifestations in the mouse model of mucopolysaccharidosis I. Molecular genetics and metabolism. 2008; 86(1-2): 233-43.
Ryazantsev S., Yu W.H., Zhao H.Z., Neufeld E.F., Ohmi K. Lysosomal accumulation of SCMAS (subunit c of mitochondrial ATP synthase) in neurons of the mouse model of mucopolysaccharidosis III B. Molecular genetics and metabolism. 2007; 90(4): 393-401.
Zheng Y., Ryazantsev S., Ohmi K., Zhao H.Z., Rozengurt N., Kohn D.B., Neufeld E.F. Retrovirally transduced bone marrow has a therapeutic effect on brain in the mouse model of mucopolysaccharidosis IIIB. Molecular genetics and metabolism. 2004; 82(4): 286-95.
Zheng Y., Rozengurt N., Ryazantsev S., Kohn D.B, Satake N., Neufeld E.F. Treatment of the mouse model of mucopolysaccharidosis I with retrovirally transduced bone marrow. Molecular genetics and metabolism. 2003; 79(4): 233-44.
Ohmi K., Greenberg D.S., Rajavel K.S., Ryazantsev S., Li H.H., Neufeld E.F. Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(4): 1902-7.
Li H.H., Zhao H.Z., Neufeld E.F., Cai Y. Gómez-Pinilla F. Attenuated plasticity in neurons and astrocytes in the mouse model of Sanfilippo syndrome type B. Journal of neuroscience research 2002; 69(1): 30-8.
Rajavel K.S., Neufeld E.F. Nonsense-mediated decay of human HEXA mRNA. Molecular and cellular biology. . 2001; 21(16): 5512-9.
Kakkis E.D., Muenzer J., Tiller G.E., Waber L., Belmont J., Passage M., Izykowski B., Phillips J., Doroshow R., Walot I., Hoft R., Neufeld E.F. Enzyme- Replacement therapy in mucopolysaccharidosis I. N. Engl. J. Med 2001; 344: 182-188.
Neufeld E.F., Muenzer J. The Mucopolysaccharidoses. The Metabolic and Molecular Bases of Inherited Disease 2001; Eighth edition: 3421-3452.
Yu W.H., Zhao K.W., Ryazantsev S., Rozengurt N., Neufeld E.F. Short-term enzyme replacement in the murine model of Sanfilippo syndrome type B. Molecular genetics and metabolism. . 2000; 71(4): 573-80.
Zhao K.W., Neufeld E.F. Purification and characterization of recombinant human alpha-N-acetylglucosaminidase secreted by Chinese hamster ovary cells. Protein expression and purification. . 2000; 19(1): 202-11.
Li H.H., Yu W.H., Rozengurt N., Zhao H.Z., Lyons K.M., Anagnostaras S., Fanselow M.S., Suzuki K.. Vanier M.T., Neufeld E.F. Mouse model of Sanfilippo syndrome type B producedby targeted disruption of the gene encoding alpha-N-acetylglucosaminidase. Proc. Natl. Acad. Sci. USA 1999; 96: 14505-14510.
Schmidtchen A., Greenberg D., Zhao H.G., Li H.H., Huang Y., Tieu P., Zhao H.Z., Cheng S. Zhao Z., Whitley C.B., Di Natale P., Neufeld E.F. NAGLU mutations underlying Sanfilippo syndrome type B. American journal of human genetics. . 1998; 62(1): 64-9.
Zhao K.W., Faull K.F., Kakkis E.D., Neufeld E.F. Carbohydrate structures of recombinant human alpha-L-iduronidase secreted by Chinese hamster ovary cells. The Journal of biological chemistry. . 1997; 272(36): 22758-65.
Zhao H.G., Li H.H., Bach G., Schmidtchen A., Neufeld E.F. The molecular basis of Sanfilippo syndrome type B. Proceedings of the National Academy of Sciences of the United States of America. . 1996; 93(12): 6101-5.
Shull R.M., Kakkis E.D., McEntee M.F., Kania S.A., Jonas A.J., Neufeld E.F. Enzyme replacement in a canine model of Hurler syndrome. Proceedings of the National Academy of Sciences of the United States of America. . 1994; 91(26): 12937-41.


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